Related Experiment Video

Updated: Jun 27, 2026

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite
07:29

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Published on: February 16, 2016

[Free radical processes and erythron in pregnant rats and their fetuses in chronic nitrite intoxication]

A S Ivanova, O G Sitnikova, S B Nazarov

    Gigiena I Sanitariia
    |December 23, 2008
    PubMed

    More Related Videos

    Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats11:01

    Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

    Published on: December 14, 2014

    Swimming Exercise Protocol and Care Methods for Pregnant Rats05:17

    Swimming Exercise Protocol and Care Methods for Pregnant Rats

    Published on: April 5, 2024

    Related Concept Videos

    Bioactivation and Tissue Toxicity01:25

    Bioactivation and Tissue Toxicity

    Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
    2° Amines to N-Nitrosamines: Reaction with NaNO201:20

    2° Amines to N-Nitrosamines: Reaction with NaNO2

    Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...