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Targetted destruction of PC3 mitochondria by ETYA: a 'Trojan horse' membrane-suicide molecule

K M Anderson1, J E Harris

  • 1Department of Medicine, Rush Medical College, Chicago, IL 60612.

Medical Hypotheses
|June 1, 1991
PubMed

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Electron Transport Chain: Complex I and II01:46

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...