Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insomnia01:27

Insomnia

Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helping Patients With Persecutory Delusions Find Safety.

Schizophrenia bulletin·2026
Same author

An excitement building in the development of psychological treatments for schizophrenia.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same author

Patient expectations for outcome with psychological intervention for psychosis.

Schizophrenia research·2026
Same author

Triggering anger using a virtual reality social scene.

Scientific reports·2026
Same author

Safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy from a first-in-human study of volrustomig, a novel PD-1/CTLA-4 bispecific antibody.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

From innovation to implementation: Artificial intelligence in cognitive behaviour therapy training and supervision.

Behaviour research and therapy·2026
Same journal

Weight loss and gut microbial changes associated with semaglutide among people living with schizophrenia receiving clozapine or olanzapine: An open-label 24-week semaglutide intervention and 76-week trial.

Schizophrenia research·2026
Same journal

Converting negative symptom dimension scores across SANS and PANSS.

Schizophrenia research·2026
Same journal

Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis.

Schizophrenia research·2026
Same journal

One social interaction after another: Dynamic modeling of social experience in schizophrenia.

Schizophrenia research·2026
Same journal

Reduced synaptic plasticity and E/I imbalance drive peripersonal space boundaries expansion in schizophrenia.

Schizophrenia research·2026
Same journal

Complete blood count-derived inflammatory markers and symptom phenotypes in schizophrenia spectrum disorders: A hierarchical clustering analysis.

Schizophrenia research·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Insomnia and paranoia.

Daniel Freeman1, Katherine Pugh, Natasha Vorontsova

  • 1Department of Psychology, Institute of Psychiatry, King's College London, United Kingdom. D.Freeman@iop.kcl.ac.uk

Schizophrenia Research
|December 23, 2008
PubMed
Summary
This summary is machine-generated.

Insomnia symptoms are linked to increased persecutory ideation, with anxiety and depression partially explaining this connection. This suggests sleep interventions may help reduce paranoia in affected individuals.

More Related Videos

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

  • Psychiatry
  • Sleep Medicine
  • Clinical Psychology

Background:

  • Insomnia is a potential precursor to anxiety, depression, and unusual experiences, which are known predictors of paranoia.
  • Existing research suggests a link between sleep disturbances and mental health conditions, but the direct association with paranoia requires further investigation.

Purpose of the Study:

  • To investigate the relationship between insomnia symptoms and paranoia in the general population.
  • To determine the prevalence of insomnia in individuals experiencing persecutory delusions within psychiatric services.

Main Methods:

  • Cross-sectional study involving 300 individuals from the general population and 30 patients with persecutory delusions and non-affective psychosis.
  • Standardized assessments were used to measure insomnia symptoms, persecutory ideation, anxiety, and depression.

Main Results:

  • A significant association was found between insomnia symptoms and higher levels of persecutory ideation.
  • Anxiety and depression partially mediated the relationship between insomnia and paranoia.
  • Over 50% of individuals with persecutory delusions reported moderate to severe insomnia.

Conclusions:

  • This study provides the first direct evidence linking insomnia to paranoia in the general population.
  • Sleep difficulties may play a role in the development and maintenance of persecutory ideation.
  • Interventions targeting insomnia could potentially alleviate paranoia in at-risk individuals.