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Updated: Jun 27, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Sleep-disordered breathing in children]
S Cohen-Gogo1, Ngoc Thanh C Do, D Levy
1Service de génétique médicale, hôpital Necker-Enfants-Malades, AP-HP, Paris, France.
Insights
Sleep-disordered breathing (SDB) in children, including obstructive sleep apnea (OSA), impacts cognitive function and carries cardiovascular risks. Early diagnosis and treatment by pediatricians are crucial public health priorities.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Child Neurology
Context:
- Sleep-disordered breathing (SDB) in children encompasses primary snoring and obstructive sleep apnea (OSA).
- 12% of children experience primary snoring, while 1-2% have OSA.
- Polysomnography is the diagnostic standard but is complex and costly.
Purpose:
- To review the diagnosis, pathophysiology, neurocognitive and cardiovascular consequences, and management of SDB in children.
- To emphasize the public health significance of SDB and the pediatrician's role.
Summary:
- SDB is linked to significant cognitive and behavioral issues, influenced by age and severity.
- Inflammation is central to SDB pathophysiology; OSA is a childhood cardiovascular risk factor.
- Adenoidotonsillectomy is primary treatment; anti-inflammatories and CPAP are alternatives.
Impact:
- Highlights the neurocognitive and cardiovascular implications of pediatric SDB.
- Underscores the need for pediatrician involvement in SDB prevention and management.
- Informs treatment strategies, from surgery to medical therapies and ventilation.
Abstract:
Sleep-disordered breathing (SDB) in children comprises a wide spectrum of symptoms ranging from primary snoring to obstructive sleep apnea (OSA). Twelve percent of children present primary snoring and 1-2% OSA. Polysomnography is the gold standard for diagnosis of SDB allowing the analysis of sleep stages, respiratory movements, airflow, and gas exchange. However, this test remains highly technical, expensive, and difficult to conduct; other simpler diagnostic methods are under evaluation. Recent studies highlight the frequency and importance of cognitive and behavioral disorders in children with SDB; both the age and the severity of the SDB seem to modulate in the expression of neurocognitive consequences. Local and systemic inflammation plays a key role in the physiopathology of SDB and its complications: OSA is a cardiovascular risk factor in childhood that could favor atheromatous complications later in life. Adenoidotonsillectomy is the treatment of choice, but anti-inflammatory therapies such as leukotriene receptor antagonists or nasal corticoids may be beneficial in mild SDB or in residual OSA after adenotonsillectomy. In case of failure, noninvasive ventilation by means of nasal continuous positive pressure will be necessary, aided by specialists. SDB and OSA are a public health problem, underlining the pivotal role of the pediatrician in preventing, diagnosing, and treating these frequent disorders.
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