Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics and outcomes of patients with pediatric-onset non-mastocytosis mast cell activation disorders: A CEREMAST study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Ibrutinib-induced spontaneous penile hematoma.

Annales de dermatologie et de venereologie·2025
Same author

KIT-Targeting Drugs in the Management of Nonadvanced and Advanced Systemic Mastocytosis.

The journal of allergy and clinical immunology. In practice·2025
Same author

Peripheral T- and natural killer-cell lymphomas: ESMO-EHA Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

A high prevalence of hereditary alpha-tryptasemia in pediatric mastocytoma.

Allergy·2024
Same author

Abatacept is useful in autoimmune cytopenia with immunopathologic manifestations caused by CTLA-4 defects.

Blood·2021

Related Experiment Video

Updated: Jun 27, 2026

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

[Mastocytosis and anaesthesia].

P Dewachter1, C Mouton-Faivre, J-B Cazalaà

  • 1Service d'anesthésie-réanimation chirurgicale, Samu de Paris, hôpital Necker-Enfants-Malades, AP-HP, université Paris-Descartes, 149, rue de Sèvres, 75443 Paris, France. pascale.dewachter@nck.aphp.fr

Annales Francaises D'Anesthesie Et De Reanimation
|December 23, 2008
PubMed
Summary

Mastocytosis, a rare condition involving mast cell accumulation, requires careful perioperative management. This review outlines strategies to prevent mast cell degranulation and manage severe cardiovascular events in patients undergoing surgery.

More Related Videos

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
06:40

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
06:40

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Published on: June 8, 2021

Area of Science:

  • Hematology
  • Immunology

Context:

  • Mastocytosis involves abnormal mast cell accumulation in tissues, affecting approximately 1 in 150,000 individuals.
  • While cutaneous forms often occur in children and may resolve, systemic mastocytosis is more common in adults and involves organ systems.
  • The condition stems from c-kit receptor mutations, leading to mast cell proliferation, migration, and degranulation, and is distinct from allergic diseases.

Purpose:

  • To review and suggest perioperative management strategies for patients with mastocytosis.
  • To highlight the importance of avoiding mast cell degranulation triggers.
  • To discuss the management of severe cardiovascular complications.

Summary:

  • Perioperative care for mastocytosis necessitates a multidisciplinary approach, focusing on trigger avoidance (psychological, chemical, physical) and managing potential degranulation.
  • Premedication has not demonstrated efficacy, but preoperative tryptase measurement is advised.
  • Severe clinical signs are linked to cardiovascular disturbances, with epinephrine and vascular loading being the primary treatment for critical events.

Impact:

  • Provides guidance for clinicians on optimizing perioperative care for mastocytosis patients.
  • Aims to reduce perioperative morbidity and mortality associated with mast cell degranulation and cardiovascular compromise.
  • Contributes to a better understanding of managing this rare hematologic disorder in surgical settings.