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Updated: Jun 27, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[Intestinal obstruction in children due to isolated intestinal malrotation. Report of 11 cases]
R Ramirez1, K Chaumoître, F Michel
1Service de chirurgie pédiatrique, hôpital Nord, AP-HM, université de la Méditerranée, chemin des Bourrelys, 13915 Marseille cedex 20, France.
Insights
Early diagnosis of intestinal malrotation in children is crucial. Prompt identification and treatment, such as the Ladd procedure, can prevent serious complications from this congenital anomaly.
Area of Science:
- Pediatric Surgery
- Gastrointestinal Motility Disorders
Background:
- Intestinal malrotation is a congenital anomaly requiring prompt diagnosis and management.
- The Ladd procedure is a common surgical intervention for symptomatic intestinal malrotation.
Observation:
- A study reviewed 11 children who underwent the Ladd procedure for intestinal malrotation between 1996 and 2007.
- Common presentations included bilious vomiting, weight loss, and melena.
- Intraoperative findings frequently involved midgut volvulus and incomplete malrotation.
Findings:
- Radiological and ultrasound investigations aided in diagnosing intestinal malrotation, though not always preoperatively.
- Seven out of eleven patients presented with midgut volvulus, a potentially life-threatening complication.
- Incomplete malrotation (180 degrees) was observed in the majority of cases.
Implications:
- Emphasizes the importance of early diagnosis of intestinal malrotation in pediatric patients.
- Highlights the effectiveness of the Ladd procedure in managing complications.
- Suggests that timely intervention can prevent severe outcomes associated with intestinal malrotation.
Unlabelled:
The purpose of this study was to determine the clinical significance of children presenting with malrotation to develop treatment recommendations.
Methods:
Records of children undergoing a Ladd procedure were identified in the pediatric patient database from 1 June 1996 to 31 March 2007. Patients with intestinal obstruction caused by isolated intestinal malrotation were included. The exclusion criteria were the association of predisposing factors (omphalocele, gastroschisis, diaphragmatic hernia). Patient characteristics, imaging investigations, operations performed, and morbidity were evaluated.
Results:
Eleven children (7 boys and 4 girls) underwent a Ladd procedure at the median age of 14 days. Seven patients presented bilious vomiting, alimentary vomiting associated with weight loss (2 cases), and melena (1 patient) at admission. The upper gastrointestinal radiological investigations established the diagnosis of intestinal malrotation in 6 cases confirmed by ultrasonography in 3 cases. Isolated Doppler ultrasound investigation was sufficient in 4 cases before abdominal surgery. In 1 case, preoperative diagnosis of intestinal malrotation was not made. Intraoperative anomalies were midgut volvulus in 7 cases, Ladd bands in 3 patients, and malrotation with intestinal ischemia in 2 cases with spontaneous resolution of midgut volvulus. Incomplete intestinal malrotation (180 degrees) was found in 10 cases and a mobile cecum in 1.
Conclusion:
These findings provide support for performing early diagnosis of intestinal malrotation to prevent the rare but potentially devastating complications of this anomaly.
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Intestinal Obstruction I: Introduction
Intestinal Obstruction II: Pathophysiology
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