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Related Concept Videos

The Proteasome02:18

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome01:13

The Proteasome

Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

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Related Experiment Video

Updated: Jun 27, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

Targeting proteasomes for cardioprotection.

Xichun Yu1, Eugene Patterson, David C Kem

  • 1Endocrinology/Harold Hamm Oklahoma Diabetes Center & Heart Rhythm Institute, University of Oklahoma Health Sciences Center, 1200 Everett Dr, Oklahoma City, OK 73104, United States. xichun-yu@ouhsc.edu

Current Opinion in Pharmacology
|December 23, 2008
PubMed
Summary
This summary is machine-generated.

The ubiquitin-proteasome system (UPS) degrades proteins and impacts heart health. Proteasome inhibitors may protect the heart in certain cardiac disease models.

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Area of Science:

  • Cellular Biology
  • Cardiovascular Science
  • Biochemistry

Background:

  • The ubiquitin-proteasome system (UPS) is crucial for protein degradation and cellular regulation.
  • Altered UPS function is implicated in various cardiac diseases, including hypertrophy, failure, ischemia, atherosclerosis, and diabetic cardiovascular disease.
  • Proteasome function impairment is common in cardiac disease, though increased activity has also been observed.

Purpose of the Study:

  • To investigate the role of the ubiquitin-proteasome system in cardiac disease pathogenesis.
  • To explore the potential cardioprotective effects of proteasome inhibitors in cardiac disease models.

Main Methods:

  • Review of existing studies on UPS function in cardiac disease.
  • Analysis of research on proteasome inhibitors in experimental cardiac disease models.

Main Results:

  • The UPS regulates critical cellular processes relevant to cardiac function.
  • Dysfunctional UPS is a significant factor in the development of diverse cardiac pathologies.
  • Proteasome inhibitors have demonstrated cardioprotective potential in specific cardiac disease contexts.

Conclusions:

  • The ubiquitin-proteasome system is a key player in cardiovascular health and disease.
  • Targeting the UPS with inhibitors represents a potential therapeutic strategy for cardiac conditions.