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Updated: Jun 27, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Myocardial delayed contrast-enhanced MRI: relationships between various enhancing patterns and myocardial diseases
E Sueyoshi1, I Sakamoto, M Uetani
1Department of Radiology, Nagasaki University School of Medicine, Nagasaki, Japan. eijunsueyoshi@aol.com
Abstract:
The concentration of MR contrast agents is relatively high in abnormal myocardial tissue, with increased extravascular space and/or abnormal contrast wash-in and wash-out characteristics. Based on this mechanism, myocardial delayed contrast-enhanced MRI has been increasingly used to detect myocardial damage. Delayed enhancement (DE) can be seen in various components, such as fibrosis, protein infiltration or possibly myocardial disarray with disorganized myocardial fibre packing. Therefore, DE can be seen in various myocardial diseases, each of which has a characteristic DE pattern. Knowledge of the relationships among various DE patterns and myocardial diseases is useful for differential diagnosis and management.
Insights
Myocardial delayed contrast-enhanced MRI detects heart damage by identifying abnormal contrast agent concentrations in damaged heart tissue. Different patterns of delayed enhancement (DE) help diagnose various heart diseases.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Cardiac MRI
Background:
- Abnormal myocardial tissue shows higher MR contrast agent concentrations.
- This is due to increased extravascular space and altered contrast kinetics.
- Myocardial delayed contrast-enhanced MRI leverages this for damage detection.
Purpose of the Study:
- To highlight the mechanism of myocardial delayed enhancement (DE).
- To explain the utility of DE patterns in diagnosing myocardial diseases.
- To emphasize the role of DE in differential diagnosis and patient management.
Main Methods:
- Utilizing the principle of increased contrast agent concentration in abnormal myocardium.
- Analyzing contrast wash-in and wash-out characteristics.
- Observing delayed enhancement (DE) patterns on cardiac MRI.
Main Results:
- Delayed enhancement (DE) is observed in abnormal myocardial tissue.
- DE can represent fibrosis, protein infiltration, or myocardial disarray.
- Distinct DE patterns are associated with specific myocardial diseases.
Conclusions:
- Myocardial delayed contrast-enhanced MRI is effective for detecting myocardial damage.
- Characteristic DE patterns aid in differentiating various myocardial diseases.
- Understanding DE patterns is crucial for accurate diagnosis and treatment planning.
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