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Related Concept Videos

Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Updated: Jun 27, 2026

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
09:35

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

The Cardiac Physiome: perspectives for the future.

James Bassingthwaighte1, Peter Hunter, Denis Noble

  • 1Department of Physiology, Anatomy & Genetics, Oxford, UK. denis.noble@dpag.ox.ac.uk

Experimental Physiology
|December 23, 2008
PubMed
Summary
This summary is machine-generated.

The 10-year Physiome Project aims to quantitatively model human physiology, integrating genetic and environmental factors. Progress is accelerating, offering optimism for a comprehensive understanding of human health.

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Last Updated: Jun 27, 2026

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Area of Science:

  • Physiology
  • Computational Biology
  • Systems Biology

Background:

  • The Physiome Project, including the Cardiac Physiome, has been active for a decade.
  • Understanding human physiology requires integrating genetic and environmental influences.

Purpose of the Study:

  • To review progress and challenges in developing a quantitative framework for human physiology.
  • To assess the integration of genetic inheritance and environmental factors in physiological models.

Main Methods:

  • Review of past progress in the Physiome Project.
  • Analysis of challenges in creating a quantitative physiological framework.
  • Discussion of incorporating genetic and environmental data.

Main Results:

  • The Physiome Project has made significant strides over the past 10 years.
  • A quantitative framework for human physiology is under development.
  • Integration of genetic and environmental influences is a key focus.

Conclusions:

  • Developing a quantitative framework for human physiology is a complex but achievable goal.
  • Accelerating progress in the Physiome Project warrants optimism for future advancements.
  • The project's success relies on integrating diverse biological data sources.