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Updated: Jun 27, 2026

Protein Misfolding Cyclic Amplification of Prions
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Prion interference with multiple prion isolates.

Charles R Schutt1, Jason C Bartz

  • 1Department of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, Nebraska 68178, USA.

Prion
|December 23, 2008
PubMed
Summary
This summary is machine-generated.

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The drowsy (DY) transmissible mink encephalopathy (TME) agent blocks other prion strains, including hamster-adapted chronic wasting disease (HaCWD) and scrapie, from causing disease. This prion strain interference may occur naturally and is a widespread phenomenon.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Veterinary Medicine

Background:

  • Prion diseases are fatal neurodegenerative disorders caused by misfolded prion proteins.
  • Prion strain interference describes how one prion strain can inhibit another's replication or disease-causing ability.
  • The drowsy (DY) strain of transmissible mink encephalopathy (TME) is known to interfere with the hyper (HY) TME strain.

Purpose of the Study:

  • To investigate if the interfering effect of the DY TME agent extends beyond the HY TME strain.
  • To determine if DY TME agent interference occurs via natural routes of infection, such as sciatic nerve or oral inoculation.
  • To assess the broader applicability of prion strain interference.

Main Methods:

  • Hamsters were intracerebrally, intraperitoneally, or via sciatic nerve inoculated with DY TME agent alone or in combination with HY TME, hamster-adapted chronic wasting disease (HaCWD), or 263K scrapie agents.

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Last Updated: Jun 27, 2026

Protein Misfolding Cyclic Amplification of Prions
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Published on: November 7, 2012

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  • Per os (oral) inoculation was used to assess interference between DY TME and HY TME agents.
  • Incubation periods and disease progression were monitored to evaluate the interfering effects.

    • Main Results:

    • DY TME agent blocked disease caused by HaCWD and 263K scrapie agents following sciatic nerve inoculation.
    • DY TME agent also extended the incubation period of HY TME agent when co-inoculated per os.
    • These findings demonstrate that DY TME agent interference is not limited to the HY TME strain and can occur via natural infection routes.

    Conclusions:

    • Prion strain interference is a more generalized phenomenon than previously thought.
    • The DY TME agent can interfere with a broader range of prion strains and infection routes.
    • Prion strain interference may play a significant role in the natural transmission and pathogenesis of prion diseases.