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Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 27, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Osteosarcoma: Conventional treatment vs. gene therapy.

Mei Lin Tan1, Peter F M Choong, Crispin R Dass

  • 1Department of Orthopaedics, University of Melbourne, St. Vincent's Hospital Melbourne, Melbourne, Australia.

Cancer Biology & Therapy
|December 23, 2008
PubMed
Summary

Osteosarcoma (OS) is a primary bone cancer in children and adolescents. This review covers current treatments like surgery and chemotherapy, and explores new options such as gene therapy for better outcomes.

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Last Updated: Jun 27, 2026

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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
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Published on: May 3, 2021

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Molecular Biology

Background:

  • Osteosarcoma (OS) is the most frequent primary malignant bone tumor in children and adolescents.
  • Current treatment modalities include surgery, radiotherapy, and chemotherapy, often with limited efficacy and significant side effects.
  • Understanding the molecular drivers of OS is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To review established clinical treatments for osteosarcoma.
  • To explore emerging experimental therapies, particularly gene therapy, for osteosarcoma.
  • To provide an overview of advancements in osteosarcoma treatment research.

Main Methods:

  • Literature review of clinical osteosarcoma treatments.
  • Examination of recent research on targeted and localized osteosarcoma therapies.
  • Analysis of gene therapy approaches for osteosarcoma.

Main Results:

  • Standard treatments like surgery, radiotherapy, and chemotherapy are detailed.
  • Emerging therapeutic strategies, including gene therapy, show promise for targeted treatment.
  • Advancements in understanding OS pathogenesis are paving the way for innovative treatments.

Conclusions:

  • Osteosarcoma treatment requires a multi-faceted approach combining established and novel therapies.
  • Gene therapy represents a promising avenue for more localized and effective osteosarcoma treatment.
  • Continued research into OS molecular mechanisms is essential for improving patient outcomes.