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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

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Expression of transforming growth factor beta1 in ameloblastomas.

Giovanna Iezzi¹, Adriano Piattelli, Corrado Rubini

¹Dental School, University of Chieti-Pescara, Italy.

The Journal of Craniofacial Surgery

|December 23, 2008

Summary

Transforming growth factor (TGF) beta1 expression is higher in high-risk ameloblastomas. This protein may promote tumor invasion in recurrent ameloblastoma cases.

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Area of Science:

Oral Pathology
Oncology
Biochemistry

Background:

Ameloblastomas (AMs) are odontogenic tumors with varying recurrence risks.
Transforming growth factor (TGF) beta1 plays complex roles in tumor progression.

Purpose of the Study:

To compare TGF-beta1 expression in ameloblastomas with different recurrence risks.
To investigate the association between TGF-beta1 and ameloblastoma invasiveness.

Main Methods:

Immunohistochemistry was used to evaluate TGF-beta1 expression.
29 ameloblastoma cases were classified into low-risk (unicystic, peripheral) and high-risk (solid) groups.

Main Results:

Higher TGF-beta1 positivity was observed in the stromal cells of high-risk ameloblastomas compared to low-risk ones (P = 0.0308).
No significant differences in TGF-beta1 immunoreactivity were found in vessels or odontogenic epithelium between groups.

Conclusions:

Elevated TGF-beta1 expression in stromal cells correlates with a higher risk of recurrence in ameloblastomas.
TGF-beta1 may contribute to the invasive phenotype of ameloblastomas in later stages.