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Related Experiment Video

Updated: Jun 27, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Prolonged ocular hypotension: would ciliary tissue transplantation help.

P G Watson¹, L Jovanovik-Pandova

¹Addenbrooke's University Hospital Cambridge, 11 Perry Court, Clerk Maxwell Road, Cambridge CB3 0RS, UK. peter.g.watson@btinternet.com

Eye (London, England)

|December 23, 2008

Summary

Transplanted ciliary tissue survived in rabbits, secreting aqueous humor and potentially reversing vision damage from hypotony. This offers a new treatment for severe eye conditions.

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Last Updated: Jun 27, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

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Published on: January 22, 2018

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

Ophthalmology
Regenerative Medicine
Transplantation Biology

Background:

Severe ocular hypotony and phthisis bulbi are challenging conditions with limited treatment options.
Complete shutdown of ciliary epithelium, crucial for intraocular pressure (IOP), is rare but devastating.
Restoring IOP through secreting ciliary tissue could prevent further visual damage or even reverse existing damage.

Purpose of the Study:

To investigate the survival and function of transplanted ciliary epithelium in a rabbit model.
To assess the potential of ciliary tissue transplantation for managing intractable ocular hypotony.

Main Methods:

Allografts of ciliary epithelium were transplanted onto the iris surface in albino rabbits.
Animals were untreated, immunosuppressed, or immunosuppressed with whole-body perfusion.
Tissue survival and function were evaluated using slit-lamp observation, staining, angiography, histology, and electron microscopy.

Main Results:

Transplanted ciliary tissue survived ischemia in the anterior chamber and became revascularized within 12 days.
Untreated rabbits showed graft rejection.
Immunosuppressed rabbits with perfusion maintained normal, aqueous-secreting ciliary epithelial tissue.

Conclusions:

Perfused allografts of ciliary tissue can survive and secrete aqueous in immunosuppressed rabbits.
Ciliary tissue transplantation shows promise as a therapeutic strategy for severe ocular hypotony.
Further research is needed to confirm efficacy in damaged eyes.