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Updated: Jun 27, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
The trefoil factor family - small peptides with multiple functionalities
1Immunopharmacology, Novo Nordisk Park, Maaloev, Denmark. skje@novonordisk.com
Abstract:
The trefoil factor family (TFF) comprises a group of small peptides which are highly expressed in tissues containing mucus-producing cells - especially in the mucosa lining the gastrointestinal tract. The peptides seem crucial for epithelial restitution and may work via other pathways than the conventional factors involved in restitution. In vitro studies have shown that the TFFs promote restitution using multiple mechanisms. The peptides also have other functionalities including interactions with the immune system. Moreover, therapeutic effects of the TFFs have been shown in several animal models of gastrointestinal damage. Still it is not clear which of their in vitro properties are involved in the in vivo mode of action. This review describes the TFF family with emphasis on their biological properties and involvement in mucosal protection and repair.
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