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Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy
Germano C Costa1, Manoel Otávio da Costa Rocha, Paula Rocha Moreira
1Laboratory of Cell-Cell Interactions, Department of Morphology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Abstract:
This study was designed to determine whether the functional IL-10 gene polymorphism -1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients' cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by left-ventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
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