[Treatment of congenital hypertrophic pyloric stenosis with endoscopic pyloromyotomy]
Related Experiment Video
Updated: Jun 27, 2026

Robotic Myotomy and Partial Fundoplication for Achalasia
Published on: August 11, 2023
You-xiang Zhang1, Yu-qiang Nie, Xue Xiao
1Department of Pediatrics, the First People's Hospital of Guangzhou, Guangzhou 510180, China.
Insights
Endoscopic pylorotomy effectively treated congenital hypertrophic pyloric stenosis in infants, enabling rapid feeding and avoiding open surgery. This safe, simple procedure showed significant symptom improvement and good long-term outcomes.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Minimally Invasive Procedures
Background:
- Congenital hypertrophic pyloric stenosis (CHPS) presents with significant infant feeding difficulties.
- Diagnosis relies on clinical signs, ultrasound, and gastrointestinal imaging.
- Associated conditions like malnutrition and metabolic alkalosis are common.
Purpose of the Study:
- To assess the efficacy and safety of endoscopic pyloromyotomy for treating CHPS.
- To evaluate the procedure's impact on infant feeding and recovery.
- To compare endoscopic approach with traditional surgical methods.
Main Methods:
- Nine infants diagnosed with CHPS underwent endoscopic pyloromyotomy.
- The procedure involved gastroscope insertion and precise muscle incisions using specialized endoscopic tools.
- Incision depth was guided by pre-operative ultrasound measurements.
Main Results:
- Successful endoscopic passage post-procedure confirmed by imaging.
- Rapid resumption of feeding within 2-10 hours post-operation.
- Significant reduction in vomiting, with complete resolution in most infants.
- No major complications like perforation or hemorrhage were reported.
- Eight infants showed positive outcomes at follow-up; one case required a repeat procedure.
Conclusions:
- Endoscopic pyloromyotomy is a safe and effective treatment for CHPS.
- The minimally invasive approach facilitates early feeding and avoids open surgery.
- This technique offers a simpler, advantageous alternative for CHPS management.
Objective:
To evaluate the effect of the treatment of congenital hypertrophic pyloric stenosis (CHPS) with endoscopic pyloromyotomy.
Method:
Nine consecutive infants (7 boys, 2 girls; age range 26 - 70 days; weight range 2.65 - 6.10 kg), with a diagnosis of CHPS according to typical clinical manifestations, transabdominal ultrasound (US), gastroenterography and gastroscope. All the cases had accompanying malnutrition, anaemia, metabolic alkalosis, and some were complicated with congenital heart disease. In gastroscope operating room, all the patients were given pentobarbital and midazolam intravenously. A gastroscope with an outer diameter of 5.9 mm was passed through mouth, stomach, pylorus to the descending segment of duodenum. Under gastroscopy, two incisions were made along the anterior and posterior wall of pylorus from the duodenal bulb to the antrum by using endoscopic electrosurgical needle knife and an arch sphincter sarcosome. Incisions were deepened by 2 to 3 procedures until the longitudinal muscle was exposed, about 2 to 4 mm according to transabdominal US performed before operation. The incision depth was 2 - 3 mm if pylorus wall was 4 - 6 mm in thickness; or 3 - 4 mm when the wall was thicker than 6 mm.
Result:
The endoscope was easily passed through the pylorus to the duodenum post-operation. The transabdominal US and gastroenterography showed that liquid easily flew through pylorus. All patients were able to have regular feeding about 2 to 10 hours after the operation. Vomiting in all patients was significantly decreased in frequency and amount, and in 8 infants vomiting stopped within 1 week, in one case it did not stop until 1 month after the treatment. Some cases showed slight adverse reaction, no perforation or massive haemorrhage in stomach or intestines occurred in any of the patients during and post-operation. Eight infants were doing well at follow-up (range 2 to 9 months). One girl had recurred vomiting at normal feeding after a period of 1 month postoperation without vomiting. This case was cured by second endoscopic pyloromyotomy.
Conclusions:
Endoscopic pyloromyotomy is effective, safe, simple, and offers several advantages: no need for open-abdomen surgery, feeding can be initiated rapidly.
Related Concept Videos
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
Pyloric Obstruction
Mitral Stenosis III: Medical Management
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...