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Published on: November 25, 2017
[Determination of the serum mannose binding lectin levels in 738 Han ethnic group children]
1Department of Clinical Immunology, Children's Hospital, Chongqing Medical University, China.
Insights
Serum mannose binding lectin (MBL) levels in Han Chinese children aged 28 days to 6 years show an abnormal distribution. No significant differences were found across various age and gender groups within this pediatric cohort.
Area of Science:
- Immunology
- Pediatrics
- Human Genetics
Background:
- Mannose-binding lectin (MBL) is a key component of the innate immune system.
- MBL plays a crucial role in pathogen recognition and complement activation.
- Understanding MBL levels in pediatric populations is important for assessing immune function.
Purpose of the Study:
- To determine the distribution of serum mannose-binding lectin (MBL) levels in Han ethnic group children.
- To establish reference ranges for serum MBL in children.
- To investigate potential age and gender-related variations in MBL levels.
Main Methods:
- Serum samples were collected from 268 umbilical cord blood specimens and 470 normal children (0-6 years) across three Chinese cities.
- Enzyme-linked immunosorbent assay (ELISA) was employed to quantify MBL concentrations.
- A control group of 87 adults from Chongqing was included for comparison.
Main Results:
- Serum MBL levels in children (28 days to 6 years) exhibited an abnormal distribution.
- Median MBL concentrations were significantly lower in newborns and cord blood samples compared to older children and adults.
- No statistically significant differences in MBL levels were observed among different age subgroups (28 days to 6 years) or between genders.
Conclusions:
- The distribution of serum MBL levels in children aged 28 days to 6 years is abnormal, but consistent across age and sex groups.
- The established reference range for serum MBL (P(2.5)-P(97.5)) in children aged 28 days to 6 years is 171 - 5079 microg/L.
- These findings provide valuable data for the interpretation of MBL levels in pediatric populations.
Objective:
To investigate the distribution of serum mannose binding lectin (MBL) levels in Han ethnic group children.
Methods:
The concentrations of MBL in serum were measured by ELISA in 268 umbilical cord blood specimens from Chongqing, Wuhan and Urumqi as well as in serum of 470 normal children aged from 0 to 6 years and 87 adults in Chongqing.
Results:
The distribution of serum MBL levels in children (28 days to 6 years) was abnormal but there was no significant difference in MBL serum levels in subjects of different ages and genders. The median concentration of MBL in serum was significantly lower in newborns (median: 1597 microg/L, range: 884 - 1825 microg/L), cord blood group (median: 1462 microg/L, range: 0 - 4604 microg/L) than in other groups (children group median: 2536 microg/L, range 0 - 7860 microg/L; adult group median: 2920 microg/L, range 98 - 6495 microg/L). While among the other sub-groups aged from 28 days-6 years (28 day group median 2299 microg/L, range 214 - 4195 microg/L; 6 months-group median 2622 microg/L, range 5 - 4637 microg/L; 2 years-6 years group 2585 microg/L, range 198 - 7860 microg/L), there was no statistically significant difference. The median serum MBL level in normal children aged from 28 days to 6 years was 2563 microg/L and the P(2.5)-P(97.5) was 171 - 5079 microg/L.
Conclusions:
The distribution of serum MBL levels in children (28 days to 6 years) was abnormal type but there was no statistically significant difference among different age and sex groups. The reference value of P(2.5)-P(97.5) in children (28 days-6 years) was 171 - 5079 microg/L.
