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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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Phagocytes
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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

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Updated: Jun 27, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

[Community-acquired methicillin-resistant Staphylococcus aureus].

Emilia Cercenado1, Enrique Ruiz de Gopegui

  • 1Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, España. ecercenado@terra.es

Enfermedades Infecciosas Y Microbiologia Clinica
|December 23, 2008
PubMed
Summary

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) causes infections in healthy individuals. Proper hygiene and targeted antibiotics like clindamycin are key to managing CA-MRSA infections.

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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly causing community-acquired (CA) infections.
  • CA-MRSA strains differ genetically from hospital-acquired strains and often produce Panton-Valentine leukocidin (PVL).
  • The USA300 clone is a prevalent CA-MRSA strain globally and in Spain.

Purpose of the Study:

  • To describe the characteristics, transmission, and treatment of community-acquired MRSA infections.
  • To highlight the differences between CA-MRSA and nosocomial MRSA.
  • To provide guidance on appropriate antimicrobial therapy and prevention strategies.

Main Methods:

  • Review of current literature on CA-MRSA epidemiology and clinical presentation.
  • Analysis of genotypic differences and virulence factors, including SCCmec type and PVL production.
  • Summary of recommended treatment protocols based on infection severity and antimicrobial susceptibility.

Main Results:

  • CA-MRSA commonly causes skin and soft tissue infections but can lead to severe conditions like necrotizing fasciitis and pneumonia.
  • CA-MRSA strains are generally susceptible to various antimicrobials, unlike nosocomial MRSA.
  • Transmission occurs through close contact, with potential involvement of animals.

Conclusions:

  • Effective management of CA-MRSA involves incision and drainage for purulent infections, with specific antibiotic choices based on severity.
  • Clindamycin, trimethoprim-sulfamethoxazole, and tetracyclines are recommended; fluoroquinolones should be avoided due to resistance.
  • Strict hygiene practices are crucial for preventing the spread of CA-MRSA.