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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

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Updated: Jun 27, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein structure prediction and model quality assessment.

Andriy Kryshtafovych1, Krzysztof Fidelis

  • 1Protein Structure Prediction Center, Genome Center, University of California Davis, Davis, CA 95616, USA. akryshtafovych@ucdavis.edu

Drug Discovery Today
|December 23, 2008
PubMed
Summary
This summary is machine-generated.

Computational modeling is essential for predicting protein structures when experimental data is limited. This review covers modern protein structure prediction methods and quality assessment techniques.

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A Protocol for Computer-Based Protein Structure and Function Prediction
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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

  • Biochemistry and Structural Biology
  • Bioinformatics and Computational Biology

Background:

  • Experimental determination of protein structures is limited, despite millions of sequenced proteins.
  • A significant gap exists between protein sequence data and experimentally solved 3D structures.
  • Predicting protein 3D structure from amino acid sequence remains a key challenge in molecular biology.

Purpose of the Study:

  • To review modern protein structure prediction techniques.
  • To highlight advances in comparative modeling for protein structure prediction.
  • To describe recent developments in theoretical model quality assessment.

Main Methods:

  • Review of computational protein structure prediction methodologies.
  • Focus on comparative modeling (homology modeling) approaches.
  • Analysis of methods for assessing the quality of theoretical protein models.

Main Results:

  • Comparative modeling is a primary strategy for bridging the sequence-structure gap.
  • Recent advancements have improved the accuracy and reliability of protein structure prediction.
  • New methods enhance the assessment of theoretical model quality.

Conclusions:

  • Computational protein structure prediction is vital for biomedical research.
  • Advances in comparative modeling and quality assessment are crucial for future progress.
  • Reliable translation of protein sequence to 3D structure is an ongoing goal.