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Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Related Experiment Video

Updated: Jun 27, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Leukemia stem cells and human acute lymphoblastic leukemia.

Kathrin M Bernt¹, Scott A Armstrong

¹Division of Hematology/Oncology, Children's Hospital, and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Seminars in Hematology

|December 23, 2008

Summary

Identifying leukemia stem cells (LSCs) in acute lymphoblastic leukemia (ALL) is crucial. Unlike acute myeloid leukemia (AML), ALL LSC existence and function remain unclear, impacting treatment strategies.

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Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia

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Modeling Chemotherapy Resistant Leukemia In Vitro

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Area of Science:

Oncology
Hematology
Cancer Biology

Background:

Cancer stem cells (CSCs) are proposed to drive tumor growth and treatment resistance.
Leukemia stem cells (LSCs) are well-characterized in acute myeloid leukemia (AML).
The role and origin of LSCs in acute lymphoblastic leukemia (ALL) are less understood.

Purpose of the Study:

To review recent findings on the existence and relevance of leukemia stem cells in ALL.
To discuss the potential cell of origin for ALL, distinguishing it from AML.

Main Methods:

Review of existing literature and clinical findings on ALL subpopulations.
Comparative analysis of LSC characteristics between ALL and AML.

Main Results:

Evidence suggests primitive cell subpopulations in clinical ALL samples.
Contrasting views exist on ALL hierarchical organization versus AML.
Current evidence in childhood ALL suggests origin from committed lymphoid progenitors.

Conclusions:

The concept of LSCs in ALL requires further investigation.
Understanding ALL LSC origin is critical for developing effective therapies.
Distinguishing ALL LSC biology from AML is essential for targeted treatment approaches.