Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Diabetic Nephropathy

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Giant peritoneal loose body - case report.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2024

Same author

Extrahepatic bile duct malignancies.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2022

Same author

Patients with neuregulin 1 (NRG1) rearranged cancer are suitable for the theranostic approach and targeted therapy.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2022

Same author

The association of depression and all-cause mortality: Explanatory factors and the influence of gender.

Journal of affective disorders·2022

Same author

Significance of transcriptionally-active high-risk human papillomavirus in sinonasal squamous cell carcinoma: Case series and a meta-analysis.

Neoplasma·2020

Same author

Benign liver angiomyolipoma: a case study.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2020

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Tumours in end-stage kidney.

M Hora¹, O Hes, T Reischig

¹Department of Urology, Charles University Hospital, Plzen, Czech Republic. horam@fnplzen.cz

Transplantation Proceedings

|December 23, 2008

Summary

Patients with end-stage kidney disease have a high risk of bilateral kidney tumors. Careful monitoring and consideration of contralateral nephrectomy are recommended, especially for transplant recipients on immunosuppression.

More Related Videos

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

Area of Science:

Nephrology
Oncology
Urology

Background:

Patients with end-stage kidney disease (ESKD) have an increased risk of renal cell carcinoma (RCC).
ESKD-associated RCC often presents as multifocal and bilateral tumors.
The optimal surgical management for unilateral RCC in ESKD patients remains unclear.

Purpose of the Study:

To investigate the occurrence of bilateral and multifocal renal tumors in patients with ESKD.
To evaluate the clinical outcomes of nephrectomy in ESKD patients with kidney tumors.
To inform surgical decision-making regarding unilateral versus bilateral nephrectomy in this population.

Main Methods:

Retrospective review of 14 ESKD patients diagnosed with kidney tumors between January 2002 and December 2006.
Analysis of surgical procedures, including unilateral and bilateral nephrectomies.
Histopathological examination of resected specimens to determine tumor characteristics.

Main Results:

Kidney tumors were found in all 19 specimens from 14 patients.
Tumors were multiple in 13 kidneys (68.4%) and solitary in 6 (31.6%).
Papillary RCC (PRCC) was the most common type (68.4%), followed by clear cell RCC (CRCC) (47.4%). One patient had myxoid liposarcoma with contralateral PRCC.

Conclusions:

There is a significant risk of bilateral kidney tumor involvement in ESKD patients.
Regular follow-up is crucial for patients undergoing unilateral nephrectomy.
Contralateral nephrectomy should be carefully considered, particularly in immunosuppressed transplant recipients, but prophylactic contralateral nephrectomy is not currently standard practice.