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Updated: Jun 27, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
ABO blood type incompatible kidney transplantation without splenectomy prepared with plasma exchange and rituximab
T Chikaraishi1, H Sasaki, H Tsutsumi
1Department of Urology, St. Marianna University, Kawasaki, Kanagawa, Japan. T.chikaraishi@gmail.com
Abstract:
We have designed a protocol for ABO-incompatible kidney transplantations based on preoperative plasmapheresis with a tacrolimus/mycophenolate mofetil/methylprednisolone/basiliximab protocol using low-dose rituximab (200 mg/body) instead of splenectomy to prevent antibody-mediated acute rejection. Eight patients successfully received transplants with this protocol. The titers of anti-A and -B antibodies as well as the number of CD20(+) cells were readily maintained at a low level posttransplantation. There were no side effects. All patients have renal transplant function with a follow-up of 1-34 months.
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