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Related Experiment Video

Updated: Jun 27, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Extracorporeal membrane oxygenation for primary allograft failure.

G Arpesella1, A Loforte, E Mikus

  • 1Department of Cardiac Surgery, Heart and Lung Transplantation Program, Bologna University, Bologna, Italy.

Transplantation Proceedings
|December 23, 2008
PubMed
Summary

Extracorporeal membrane oxygenation (ECMO) effectively supports heart transplant patients with primary graft failure. Rapid ECMO implementation stabilizes hemodynamics, enabling potential myocardial recovery and successful patient discharge.

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Area of Science:

  • Cardiology
  • Cardiovascular Surgery
  • Critical Care Medicine

Background:

  • Primary graft failure is a critical complication following heart transplantation.
  • Patients with severe cardiogenic shock often require advanced circulatory support.
  • Early intervention is crucial for improving outcomes in heart transplant recipients.

Purpose of the Study:

  • To evaluate the effectiveness and utility of extracorporeal membrane oxygenation (ECMO) in managing primary graft failure after heart transplantation.
  • To assess the impact of rapid ECMO implantation on hemodynamic stabilization and myocardial recovery.

Main Methods:

  • A retrospective analysis of 11 heart transplant patients who underwent ECMO implantation between July 2002 and March 2007.
  • ECMO was implanted either centrally in the operating room or peripherally in the intensive care unit.

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Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion
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Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

Published on: June 14, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion
09:47

Exploring Alternative Perfusion Solutions Using Next-Generation Polymerized Hemoglobin-Based Oxygen Carriers in a Model of Rat Ex Vivo Lung Perfusion

Published on: June 14, 2024

  • Patients presented with severe cardiogenic shock, pulmonary hypertension, or graft arrest.

    • Main Results:

    • Ten out of eleven patients were successfully weaned from ECMO after a mean support duration of 9.1 days.
    • All successfully weaned patients were discharged from the hospital, with no retransplantations required.
    • One patient experienced a fatal cerebral hemorrhage while on circulatory support.

    Conclusions:

    • Rapid implementation of extracorporeal membrane oxygenation, whether in the operating room or at the bedside, is beneficial for heart transplant patients experiencing primary graft failure.
    • ECMO facilitates hemodynamic stabilization, potentially leading to myocardial recovery and improved survival rates.
    • This study highlights ECMO as a valuable tool in managing critical complications post-heart transplantation.