Related Experiment Video
Updated: Jun 27, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
Utilization of analgesics, sedatives, and pain scores in infants with a prolonged hospitalization: a prospective
Denise Harrison1, Peter Loughnan, Elizabeth Manias
1School of Nursing, The University of Melbourne, Australia. denise.harrison@utoronto.ca
Insights
Critically ill infants in neonatal intensive care units received significant amounts of pain and sedation medications, but their pain scores were infrequently documented. This highlights a need for improved pain management strategies in this vulnerable population.
Area of Science:
- Neonatal Intensive Care
- Pediatric Critical Care
- Pain Management
Background:
- Critically ill infants in neonatal intensive care units (NICUs) often require analgesia and sedation.
- Effective pain management is crucial for improving outcomes in neonates.
Purpose of the Study:
- To describe the use of analgesic and sedative medications.
- To assess the documentation of pain scores in critically ill infants.
Main Methods:
- Prospective, longitudinal cohort study.
- Infants with a predicted length of stay of at least 28 days were included.
- Daily collection of medication dosages, routes, and pain score documentation.
Main Results:
- 55 infants were enrolled; all received oral sucrose.
- Morphine, acetaminophen, chloral hydrate, and midazolam were commonly administered.
- Pain scores were documented for only 65% of infants and infrequently recorded.
Conclusions:
- Substantial and varied use of analgesics and sedatives was observed.
- Infrequent documentation of pain assessment scores indicates a gap in care.
- Clinical implications necessitate careful consideration of pain and distress management in neonates.
Aim:
Describe the utilization of analgesic and sedative medications and documentation of pain scores in a cohort of critically ill infants in a neonatal intensive care unit.
Method:
A prospective, longitudinal, cohort study of infants with a predicted length of stay > or =28 days. Dosages and routes of administration of analgesic and sedative medications and documentation of pain scores were collected on a daily basis.
Results:
55 infants were enrolled into the study. Oral sucrose was administered to all 55 infants, 51 infants (93%) were administered enteral acetaminophen and 50 (91%) infants were administered morphine during their hospitalization. Sedatives were administered to 42 infants (76%); 36 (65%) were administered chloral hydrate and 32 (58%) were administered intravenous midazolam. With the exception of the first week of admission, when there was highest utilization of opioids and lower use of sucrose, acetaminophen and sedatives, the pattern of administration of analgesic and sedative agents remained relatively constant throughout the hospitalization. Pain scores were documented for 36 (65%) infants during their hospitalisation, however for these 36 infants, pain scores were infrequently recorded.
Conclusion:
There was substantial and varied analgesic and sedative use in this cohort of infants, yet infrequent documentation of pain assessment scores. These practices highlight important clinical implications for sick infants requiring careful consideration of pain and distress management.
Related Concept Videos
Parenteral Anesthetics: Overview
Analgesia and Pain Management
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...