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Related Experiment Videos

[Enterococcus faecalis bacteremia].

J Gómez1, V Baños, M Sempere

  • 1Servicio de Medicina Interna, Hospital Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia.

Medicina Clinica
|June 22, 1991
PubMed
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Enterococcus faecalis (E. faecalis) bacteremia is a growing concern in hospitals. Understanding its risk factors and prognosis is crucial for effective prevention and treatment strategies.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Enterococcus faecalis (E. faecalis) is increasingly implicated in hospital-acquired infections, contributing to significant morbidity and mortality.
  • The development of antimicrobial resistance in E. faecalis necessitates a deeper understanding of its clinical impact.

Purpose of the Study:

  • To define the epidemiological characteristics of E. faecalis bacteremia.
  • To identify factors predicting the development of E. faecalis bacteremia.
  • To determine prognostic indicators for mortality in patients with E. faecalis bacteremia.

Main Methods:

  • A retrospective evaluation of 57 cases of E. faecalis bacteremia.
  • Clinical and epidemiological data were collected at multiple time points during and after therapy.

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  • Therapeutic effectiveness was assessed by cure rates, mortality, and survival.
  • Main Results:

    • E. faecalis bacteremia incidence was 5.9%, with 78% being hospital-acquired and often originating from surgical services.
    • Predictive factors for bacteremia included male sex, hospitalization, severe underlying disease, prior antibiotic use (cephalosporins, ciprofloxacin), and instrumentation.
    • Factors associated with higher mortality included severe underlying disease, critical initial condition, broad-spectrum antibiotic use, polymicrobial bacteremia, and complications. Resistance to kanamycin was 42%, while amikacin resistance was 1%.

    Conclusions:

    • Enhanced knowledge of predictive and prognostic factors for E. faecalis bacteremia is essential.
    • This understanding is critical for developing targeted prevention and treatment strategies.
    • Addressing E. faecalis infections requires a comprehensive approach considering epidemiology, risk factors, and antimicrobial resistance patterns.