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Effects of amphetamine on T-cell immune response in mice
M Freire-Garabal1, J L Balboa, M J Núñez
1Department of Pharmacology, School of Medicine, University of Santiago de Compostela, Spain.
Life Sciences
|January 1, 1991
Abstract:
Mice chronically injected with amphetamine (0.4 mg/kg/day) showed a reduction in thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells was assessed and amphetamine was found to inhibit T-cell proliferation. Amphetamine also reduced the capacity of mice to the development and passive transfer of immunity to Listeria monocytogenes.