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Updated: Jun 26, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Gingival squamous cell carcinoma in adolescence
Victoria L Woo1, Robert D Kelsch, Lan Su
1Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, NV, USA.
Summary
Gingival squamous cell carcinoma (SCC) is exceptionally rare in adolescents, especially in healthy individuals. This study details four cases, highlighting diagnostic challenges and rarity in this demographic.
Area of Science:
- Oral Oncology
- Adolescent Medicine
- Pathology
Background:
- Squamous cell carcinoma (SCC) is uncommon in adolescents, typically linked to genetic or immune disorders.
- Oral SCC incidence in this age group is notably low, with tongue and lip lesions being more documented.
Observation:
- This report presents four cases of gingival SCC in adolescents without prior health conditions.
- Initial clinical assessments mimicked conditions like factitial injury or inflammation.
- Microscopic examination revealed similarities to pseudoepitheliomatous hyperplasia and keratoacanthoma.
Findings:
- Adolescent gingival SCC is exceedingly rare, posing diagnostic difficulties for clinicians and pathologists.
- The study underscores the challenge in differentiating gingival SCC from benign conditions in young patients.
Implications:
- Early recognition and accurate diagnosis are crucial for effective management of adolescent gingival SCC.
- Further research into potential etiologic factors and long-term prognosis is warranted for this rare malignancy.
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