Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tight Junctions

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

Tension Response at Adherens Junctions

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...

The Extracellular Matrix

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting cancer-specific mutations with RNA-triggered chromatin shredding.

Nature·2026

Same author

Impact of fluid overload on body composition and nutritional status in hemodialysis patients: insights from a prospective study.

Kidney research and clinical practice·2026

Same author

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding.

bioRxiv : the preprint server for biology·2026

Same author

Amplified genome editing by <i>in vivo</i> editor production.

bioRxiv : the preprint server for biology·2026

Same author

Successful Cataract Surgery in a Patient with a Port Delivery System Implant for Diabetic Macular Edema.

Case reports in ophthalmology·2026

Same author

Efficient <i>in vivo</i> mammalian neuron editing using peptide-mediated CRISPR enzyme delivery.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Matricellular proteins in the trabecular meshwork.

Douglas J Rhee¹, Ramez I Haddadin, Min Hyung Kang

¹Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA 02114, USA. dougrhee@aol.com

Experimental Eye Research

|December 23, 2008

Summary

Matricellular proteins are key to regulating intraocular pressure (IOP) and may be involved in glaucoma. Further research into these proteins could reveal new therapeutic targets for IOP dysregulation.

More Related Videos

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Related Experiment Videos

Last Updated: Jun 26, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

Ophthalmology and cellular biology.

Background:

The trabecular meshwork (TM) is crucial for regulating intraocular pressure (IOP), a major risk factor for primary open-angle glaucoma.
Matricellular proteins influence cell-extracellular matrix interactions and fibrosis in non-ocular tissues.
ECM turnover is vital for aqueous humor outflow facility, suggesting a role for matricellular proteins in IOP regulation.

Purpose of the Study:

To explore the role of matricellular proteins in the trabecular meshwork and their potential involvement in intraocular pressure (IOP) regulation and glaucoma.
To investigate specific matricellular proteins like SPARC, thrombospondins, tenascins, and osteopontin within the TM.

Main Methods:

Localization of specific matricellular proteins (SPARC, thrombospondins-1 and -2, tenascins-C and -X, osteopontin) within the trabecular meshwork.
Review of preliminary evidence regarding the functional roles of these proteins in IOP regulation.

Main Results:

Several matricellular proteins have been identified in various regions of the trabecular meshwork.
Preliminary data suggest SPARC and thrombospondin-1 are implicated in IOP regulation and potentially glaucoma pathophysiology.

Conclusions:

Matricellular proteins show promise as key players in intraocular pressure (IOP) dysregulation.
These proteins represent potential therapeutic targets for managing glaucoma and related conditions.
Further investigation is required to fully elucidate the specific roles of matricellular proteins in the trabecular meshwork.