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Updated: Jun 26, 2026

Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
Published on: March 5, 2019
Physical and functional interactions between hnRNP K and PRMT family proteins
James Yi-Hsin Chan1, Tsai-Yuan Hsieh, Shu-Ting Liu
1Graduate Institute of Medical Sciences, National Defense Medical Center, Room 7102, 161, Section 6, MinChuan, Taipei 114, Taiwan, ROC.
Abstract:
The mechanism underlying the protein-protein interaction of hnRNP K and PRMT family proteins is unclear. We examined and confirmed the arginine methylation of hnRNP K protein by PRMT1, not CARM1, via their direct binding. We also studied hnRNP K protein complexes containing CARM1, as well as PRMT1, using co-immunoprecipitation analysis. PRMT family proteins might be involved in the regulation of hnRNP K functions in nuclear receptor coactivator, transactivation, and p21 gene and protein expressions. We believe these observations will help provide insights into the regulation of hnRNP K protein functions via the recruitment of its associated proteins, including its arginine methylation-modifying proteins.
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