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Olmesartan clinical trial in Okinawan patients under OKIDS (OCTOPUS) study: design and methods

Kunitoshi Iseki1, Kiyoyuki Tokuyama2, Yoshiki Shiohira3

  • 1Dialysis Unit, University Hospital of The Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan. chihokun@med.u-ryukyu.ac.jp.

Clinical and Experimental Nephrology
|December 23, 2008
PubMed

Insights

This study investigates blood pressure targets and renin-angiotensin system inhibitors for hypertensive hemodialysis patients. Findings will guide treatment for this high-risk cardiovascular disease population.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Management

Background:

  • Chronic hemodialysis (HD) patients have high cardiovascular disease (CVD) mortality.
  • Hypertension treatment guidelines are lacking for the HD population.
  • Survival rates are higher in hypertensive HD patients compared to normotensive or hypotensive patients.

Purpose of the Study:

  • To establish target pre-dialysis blood pressure levels for hypertensive HD patients.
  • To compare the efficacy of renin-angiotensin system (RAS) inhibitors versus non-RAS inhibitors in this population.
  • To evaluate the role of home blood pressure monitoring in managing hypertension in HD patients.

Main Methods:

  • Prospective randomized controlled trial (Okinawa Dialysis Study, OKIDS).
  • Comparison of Olmesartan (RAS inhibitor) with non-RAS inhibitors in 462 ambulatory HD patients (age 20-79).
  • Inclusion criteria: resistant hypertension (pre-HD BP ≥ 140/90 mmHg) for at least 1 month.

Main Results:

  • The study aims to provide evidence on optimal blood pressure targets.
  • It will determine the impact of RAS inhibitors on mortality and CVD events over 3 years.
  • The effectiveness of home blood pressure monitoring will be assessed.

Conclusions:

  • This research will offer crucial insights into hypertension management for hemodialysis patients.
  • Findings are expected to inform clinical practice regarding blood pressure targets and antihypertensive drug selection.
  • The study will highlight the potential benefits of RAS inhibitors and home blood pressure monitoring.
Abstract

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