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Non-invasive Assessment of Microvascular and Endothelial Function

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Recent progress in analytical capillary ITP.

Petr Gebauer¹, Zdena Malá, Petr Bocek

¹Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Brno, Czech Republic.

Electrophoresis

|December 23, 2008

Summary

Capillary Isotachophoresis (ITP) offers significant preconcentration and separation of trace analytes. This review details advancements in analytical capillary ITP since 2006, covering theory, methods, and applications.

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Area of Science:

Analytical Chemistry
Separation Science

Background:

Isotachophoresis (ITP) is a powerful electrophoretic technique for concentrating trace analytes.
Capillary ITP is widely used due to its ability to concentrate samples by orders of magnitude.
ITP enables simultaneous preconcentration and separation of analytes.

Purpose of the Study:

To review the progress in analytical capillary Isotachophoresis (ITP) since 2006.
To summarize theoretical, methodological, and application-based advancements.
To include studies utilizing ITP in multistage separation schemes.

Main Methods:

Review of 90 peer-reviewed papers published since 2006.
Analysis of theoretical developments in ITP.
Assessment of methodological innovations and analytical applications.

Main Results:

Significant progress in analytical capillary ITP theory and methodology.
Diverse analytical applications demonstrating ITP's utility.
Continued integration of ITP as a crucial first step in complex separation strategies.

Conclusions:

Analytical capillary ITP remains a vital technique for trace analyte analysis.
Recent advancements have expanded its theoretical and practical scope.
ITP's role in preconcentration and separation is essential for complex analytical challenges.