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Updated: Jun 26, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Chiral guanidine catalyzed enantioselective reactions
1Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.
Abstract:
Chiral guanidine catalysts share common characteristics such as high pK(a) values and dual hydrogen-bonding modes of activation, and high catalytic activities and enantioselectivities can often be achieved. The utilization of guanidines as catalysts has been growing at a steady pace. In the past few years, it has attracted tremendous attention through several landmark achievements. This article highlights the development of chiral guanidine catalysis in asymmetric synthesis.
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