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Related Concept Videos

Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...

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Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat
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[Progress on interface membrane around prostheses].

Shu-feng Yang1, Jian-ning Zhao

  • 1Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China.

Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology
|December 24, 2008
PubMed
Summary
This summary is machine-generated.

Aseptic loosening, a common complication of joint replacement, is linked to the interface membrane. Understanding this membrane

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Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Immunology

Context:

  • Aseptic loosening is a primary cause of joint replacement failure, limiting prosthesis longevity.
  • Interface membranes surrounding orthopedic implants are critical in the pathogenesis of aseptic loosening.
  • Macrophagocytes and desmocytes within these membranes play key roles in osteolysis.

Purpose:

  • To provide a comprehensive review of the interface membrane in the context of aseptic loosening.
  • To elucidate the formation, cellular composition, osteolysis factors, immune responses, and turnover of interface membranes.
  • To highlight recent advances in understanding interface membranes for improved aseptic loosening management.

Summary:

  • This review examines the interface membrane, a key factor in aseptic loosening after joint replacement.
  • It details the membrane's formation, cellular elements (macrophagocytes, desmocytes), osteolytic factors, immune reactions, and remodeling processes.
  • The study synthesizes current knowledge on interface membranes to explain the pathology of aseptic loosening.

Impact:

  • Advances in understanding interface membranes can lead to novel therapeutic strategies for aseptic loosening.
  • Improved comprehension of membrane biology may enhance the longevity and success of joint replacement prostheses.
  • This review provides a foundation for future research into preventing and treating implant-associated osteolysis.