Related Experiment Video
Updated: Jun 26, 2026
04:08
Evaluation of the Effectiveness of Longitudinal Incision for Endoscopic Submucosal Excavation of Gastric Subepithelial Lesions
Published on: April 28, 2026
Prolonged antibiotic prophylaxis longer than 24 hours does not decrease surgical site infection after elective
Taketoshi Suehiro1, Teijiro Hirashita, Shinichiro Araki
1Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan. tsuehiro@med.gunma-u.ac.jp
Hepato-Gastroenterology
|December 24, 2008
Summary
Extending antibiotic prophylaxis beyond 2.3 days did not lower surgical site infection (SSI) rates in digestive surgery. Focus should shift from prolonged antibiotic use to multimodal strategies for preventing postoperative wound infections.
Area of Science:
- Surgical Oncology
- Infectious Disease
- Clinical Pharmacology
Background:
- Antibiotic prophylaxis is standard for reducing postoperative morbidity and costs.
- Current guidelines recommend discontinuing antimicrobial prophylaxis within 24 hours post-surgery in Western countries.
- Optimal duration of perioperative antibiotic prophylaxis for gastrointestinal surgery remains unclear.
Purpose of the Study:
- To analyze the relationship between the duration of antibiotic prophylaxis and surgical site infection (SSI) rates.
- To investigate SSI incidence in gastric and colorectal surgery based on antibiotic prophylaxis duration.
Main Methods:
- A study of 228 patients undergoing digestive surgery (gastric, colon, rectal).
- Analysis of SSI rates correlated with the duration of prophylactic antibiotic administration.
Main Results:
- Overall SSI rate was 12.2% (28/228 patients).
- Patients with SSI had longer operative times, greater blood loss, and significantly longer antibiotic prophylaxis duration (3.5 days) compared to those without SSI (2.3 days).
- Increasing antibiotic prophylaxis duration beyond 2.3 days did not correlate with a decreased SSI rate.
Conclusions:
- The rate of postoperative surgical site infection did not decrease with extended antimicrobial prophylaxis.
- Postoperative wound infection is multifactorial; reliance solely on antibiotics is insufficient.
- Surgeons should implement multimodal approaches to mitigate the risk of postoperative SSI.
Related Concept Videos
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
01:26Peptic Ulcer Disease IV: Management
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
01:25Endoscopic Procedures II: Colonoscopy
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...