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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Related Experiment Video

Updated: Jun 26, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Basosquamous carcinoma.

Carlos Garcia1, Eduardo Poletti, A Neil Crowson

  • 1Department of Dermatology at the Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA.

Journal of the American Academy of Dermatology
|December 24, 2008
PubMed
Summary
This summary is machine-generated.

Basosquamous carcinoma, an aggressive form of basal cell carcinoma (BCC), requires precise definition due to confusing terminology. Complete surgical excision is recommended, with Mohs micrographic surgery being ideal for this BCC subtype.

Related Experiment Videos

Last Updated: Jun 26, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Area of Science:

  • Dermatology
  • Oncology
  • Surgical Pathology

Background:

  • Basosquamous carcinoma is often described as an aggressive variant of basal cell carcinoma (BCC).
  • Existing literature presents confusing terminology and limited data regarding its distinct clinical behavior.
  • Contradictory surgical experiences highlight the need for clearer definition and understanding.

Purpose of the Study:

  • To define basosquamous carcinoma (BCC) and clarify its incidence, clinical behavior, and optimal treatment.
  • To review existing literature and propose a more precise diagnostic definition.
  • To address the confusing terminology and establish uniform language for this BCC subtype.

Main Methods:

  • A narrative review of MEDLINE-searched English articles was conducted.
  • A manual search of prominent dermatology textbooks was performed.
  • The review focused on defining basosquamous carcinoma, its incidence, behavior, and treatment.

Main Results:

  • No specific clinical features differentiate basosquamous carcinoma from other BCCs; diagnosis requires biopsy.
  • Histologic definitions vary, but the authors define it as infiltrative BCC with keratinization and stromal reaction.
  • Reported incidence ranges from 1.2% to 2.7%, with recurrence rates of 12-51% (excision) vs. 4% (Mohs surgery) and metastasis incidence of at least 5%.

Conclusions:

  • Terminology surrounding basosquamous carcinoma is inconsistent, necessitating a standardized definition.
  • While incidence is unclear, literature suggests a more aggressive behavior compared to typical BCC.
  • Complete surgical excision is the preferred treatment, and basosquamous carcinoma is well-suited for Mohs micrographic surgery.