Related Experiment Video
Updated: Jun 26, 2026

Colorimetric Assessment of Deiodinase 1 Activity in Human Liver Microsomes Using the Sandell-Kolthoff Reaction
Published on: April 10, 2026
Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes
Séverine Derbré1, Nathalie Lecat-Guillet, Florence Pillon
1Commissariat à l'Energie Atomique, Institut de Biologie et Technologies de Saclay (iBiTecS), Service de chimie bioorganique et de marquage, Gif-sur-Yvette F-91191, France.
Abstract:
Four photoreactive analogues of 3-biphenyl-4'-yl-5,6-dihydroimidazo[2,1-b]thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes.
Related Concept Videos
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Redox Titration: Iodimetry and Iodometry

