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Related Experiment Videos

Decrease in blood histamine in drug-treated parkinsonian patients.

M H Coelho1, I J Silva, M S Azevedo

  • 1Instituto de Química Fisiológica, Serviço de Neurologia, Faculdade de Medicina de Lisboa, Portugal.

Molecular and Chemical Neuropathology
|April 1, 1991
PubMed
Summary

Parkinson disease (PD) patients have higher blood histamine levels. L-dopa therapy, especially with anticholinergics, significantly reduces this histamine, suggesting a link between central nervous system and blood histamine.

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Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Parkinson disease (PD) is a neurodegenerative disorder.
  • Histamine plays a role in neurotransmission and immune responses.
  • Alterations in histamine levels may be associated with PD pathogenesis.

Purpose of the Study:

  • To investigate blood histamine and serum histaminase activity in Parkinson disease patients.
  • To assess the impact of L-dopa and anticholinergic therapy on histamine levels in PD.

Main Methods:

  • Blood histamine and serum histaminase levels were measured.
  • Comparison between untreated PD patients, treated PD patients, and healthy controls.
  • Analysis of therapy effects, including L-dopa + carbidopa and additional anticholinergics.

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Main Results:

  • Untreated PD patients exhibited significantly elevated blood histamine compared to controls.
  • L-dopa + carbidopa therapy led to a significant reduction in blood histamine.
  • The addition of anticholinergics further accentuated the decrease in blood histamine.
  • No significant changes were observed in plasma histaminase activity.

Conclusions:

  • The central nervous system (CNS) may influence blood histamine concentrations.
  • Elevated blood histamine in PD could be linked to increased neuronal destruction.
  • Therapeutic interventions targeting dopaminergic pathways can modulate histamine levels in PD.