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Updated: Jun 26, 2026
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
[Study on T cell subsets in HIV/AIDS patients]
Hai-Ying Li1, Zhen-Huan Cao, Yun-Xia Ji
1Beijing You'an Hospital, Capital Medical University, Beijing 100069 China.
Objective:
Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development.
Methods:
T cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM.
Results:
With diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different.
Conclusions:
The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.
