Related Experiment Videos
[Experience with velcade administration in multiple myeloma]
Aim:
To study efficacy of velcade therapy for progressive or resistant multiple myeloma (MM).
Material And Methods:
We used velcade in therapy of 36 patients (18 males and 18 females, age 43-76, age median 58 years) with progressive or resistant MM from April 2006 to February 2008. Prior second line standard therapy failed. A total of 206 courses of treatment were performed.
Results:
Treatment outcomes were assessed in 34 patients, 2 patients continue treatment. Overall response was 55.9% (EBMT criterion). A complete, partial and minimal responses were achieved in 10, 4 and 5 cases, respectively. No response was observed in 11 patients. Velcade was administered in polyresistance to polychemotherapy (PCT) programs including VAD (5 patients), contraindications for PCT because of old age or comorbid pathology (13 patients). These patients received 1-9 courses of velcade (as monotherapy in 28 patients, in combination with high-dose dexamethasone in 6 patients, in combination with high-dose dexamethasone and doxorubicin in 3 patients with progressive disease). Follow-up of this group from the start of velcade therapy was 4-15 months. Velcade induced stabilization of the disease in 4 patients (follow-up median was 8 months), progression of the disease in 5-9 months occurred in 6 patients.
Related Concept Videos
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Dosage Regimen: Multiple Oral Dosage
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Drug Dosing: Geriatric Patients
Rational Dosage Regimen: Maintenance Dose and Loading Dose
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...