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Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Related Experiment Video

Updated: Jun 26, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Endothelial dysfunction in scleroderma systematica: clinicopathogenetic correlations].

A V Volkov, E S Mach, N G Guseva

    Terapevticheskii Arkhiv
    |December 25, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Scleroderma patients exhibit impaired vascular tone regulation and reduced microcirculation. Laser Doppler flowmetry reveals neuroendothelial dysfunction contributing to systemic sclerosis vascular issues.

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    Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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    Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

    Published on: March 24, 2017

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    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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    Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
    08:09

    Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

    Published on: March 24, 2017

    Area of Science:

    • Vascular biology and microcirculation research.
    • Rheumatology and autoimmune disease studies.
    • Biomedical engineering and signal processing.

    Context:

    • Scleroderma (systemic sclerosis) patients often experience vascular complications.
    • Understanding vascular tonicity regulation is crucial for managing scleroderma.
    • Laser Doppler flowmetry (LDF) offers a method to assess microcirculatory function.

    Purpose:

    • To evaluate vascular tonicity regulation disturbances in scleroderma systematica (SS) patients.
    • To utilize laser Doppler flowmetry (LDF) with wavelet-transformation for analyzing blood flow variability.
    • To investigate microcirculation and endothelial function in SS patients.

    Summary:

    • Scleroderma patients show higher blood flow variability and reduced microcirculation in the skin.
    • A correlation exists between skin lesion severity and endothelial fluctuation amplitude.
    • SS patients demonstrate impaired flow-dependent dilation of the brachial artery, independent of cardiovascular risk factors.

    Impact:

    • Identifies specific vascular regulatory defects in scleroderma patients.
    • Highlights the role of neuroendothelial dysfunction in systemic sclerosis pathogenesis.
    • Demonstrates LDF's utility in detecting microcirculatory changes in SS.