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Updated: Jun 26, 2026
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Myocardial perfusion imaging to assess ischemia using multislice computed tomography
Jacob M van Werkhoven1, Joanne D Schuijf, Jeroen J Bax
1Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. j.m.van_werkhoven@lumc.nl
Expert Review of Cardiovascular Therapy
|December 25, 2008
Summary
Multislice computed tomography (MSCT) coronary angiography can now assess myocardial perfusion. This advanced imaging technique shows potential for evaluating both coronary anatomy and blood flow in a single, noninvasive procedure.
Area of Science:
- Cardiovascular imaging
- Medical diagnostics
- Radiology
Background:
- Multislice computed tomography (MSCT) coronary angiography accurately visualizes coronary anatomy but lacks functional assessment.
- Current limitations prevent determining the functional significance of detected coronary lesions.
- Myocardial infarction and viability can be assessed using MSCT perfusion imaging at rest.
Purpose of the Study:
- To describe the feasibility of myocardial perfusion imaging using MSCT.
- To explore the potential clinical applications of MSCT for assessing myocardial perfusion.
- To investigate the capability of MSCT to determine ischemia through stress perfusion imaging.
Main Methods:
- Utilizing recent advancements in MSCT scanner technology for myocardial perfusion imaging.
- Performing rest and stress perfusion imaging with MSCT.
- Assessing myocardial viability through delayed enhancement imaging.
Main Results:
- MSCT perfusion imaging demonstrates potential for detecting myocardial infarction and assessing viability.
- The capability of MSCT to detect ischemia during stress is under investigation.
- Limited data suggest MSCT can assess both coronary anatomy and myocardial perfusion.
Conclusions:
- MSCT myocardial perfusion imaging is feasible and shows promise for clinical use.
- This technique offers the potential for a comprehensive, noninvasive assessment of coronary artery disease.
- Future research is needed to fully establish the role of MSCT perfusion imaging in clinical practice.
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