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Published on: September 11, 2015
Permeability evaluation of 45S5 Bioglass-based scaffolds for bone tissue engineering
Ignacio Ochoa1, José A Sanz-Herrera, José M García-Aznar
1Aragon Institute of Engineering Research (I3A), Group of Structural Mechanics and Materials Modelling, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Universidad de Zaragoza, 50018 Zaragoza, Spain.
Abstract:
Permeability is a key parameter for microstructural design of scaffolds, since it is related to their capability for waste removal and nutrients/oxygen supply. In this framework, Darcy's experiments were carried out in order to determine the relationship between the pressure drop gradient and the fluid flow velocity in Bioglass-based scaffolds to obtain the scaffold's permeability. Using deionised water as working fluid, the measured average permeability value on scaffolds of 90-95% porosity was 1.96 x 10(-9) m(2). This value lies in the published range of permeability values for trabecular bone.
