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Hand-preference and population schizotypy: a meta-analysis.

M Somers¹, I E Sommer, M P Boks

¹Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, B01.206, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. M.Somers@umcutrecht.nl

Schizophrenia Research

|December 25, 2008

Summary

Non-right-handed individuals, particularly mixed-handers, exhibit higher schizotypy scores, potentially linked to bilateral language processing. This finding suggests a connection between handedness, brain organization, and schizophrenia spectrum traits.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Schizophrenia patients display less lateralized (more bilateral) language functions compared to healthy individuals.
Decreased language lateralization is also noted in those at higher risk for schizophrenia.
Language lateralization is associated with handedness, with left- and mixed-handedness linked to reduced lateralization.

Purpose of the Study:

To investigate the precise association between handedness and population schizotypy.
To clarify inconsistent previous findings linking schizotypy and left-handedness.

Main Methods:

Conducted meta-analyses on existing literature concerning handedness and schizotypy.
Compared schizotypy scores across different handedness groups (right-handed, non-right-handed, strong left-handers, mixed-handers).

Main Results:

Non-right-handed individuals, excluding strong left-handers, scored higher on schizotypy questionnaires than right-handed subjects.
Mixed-handers showed a trend towards higher schizotypy compared to strong left-handers.
These findings suggest a link between non-right-handedness and elevated schizotypy.

Conclusions:

The higher schizotypy in non-right-handed individuals may reflect a greater prevalence of bilateral language lateralization in this group.
Bilateral language organization could contribute to loosening of associations, potentially increasing schizotypy scores.
Handedness serves as a potential indicator for altered brain organization related to schizophrenia spectrum traits.