Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signals arising from antigen-presenting cells.

R M Steinman1, J W Young

  • 1Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021.

Current Opinion in Immunology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shorter heels are linked with greater elastic energy storage in the Achilles tendon.

Scientific reports·2021
Same author

Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics.

Neuroscience and biobehavioral reviews·2020
Same author

Ontogenetic allometry and architectural properties of the paravertebral and hindlimb musculature in Eastern cottontail rabbits (Sylvilagus floridanus): functional implications for developmental changes in locomotor performance.

Journal of anatomy·2019
Same author

Long-term prognosis for 1-year relapse-free survivors of CD34+ cell-selected allogeneic hematopoietic stem cell transplantation: a landmark analysis.

Bone marrow transplantation·2017
Same author

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.

Psychopharmacology·2017
Same author

Bioenergetics, Trophic Ecology, and Niche Separation of Tunas.

Advances in marine biology·2016

Antigen-presenting cells (APCs) offer more than just the two-signal model for T-cell activation. A more complex view includes peptide-MHC formation, cytokines, molecular interactions, and in situ functions for a comprehensive understanding of immune responses.

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Biology

Background:

  • The traditional view posits antigen-presenting cells (APCs) provide two signals for T-cell activation: antigen presentation and co-stimulation.
  • This two-signal model has been the cornerstone of understanding T-cell immunity for decades.

Purpose of the Study:

  • To challenge the oversimplified two-signal model of APC function.
  • To propose a more comprehensive framework for understanding APC-T cell interactions.
  • To highlight the multifaceted roles of APCs in immune responses.

Main Methods:

  • Review and synthesis of recent immunological literature.
  • Analysis of established and emerging concepts in T-cell activation.
  • Conceptual framework development based on current research.

Related Experiment Videos

Main Results:

  • The established two-signal model is an oversimplification of APC roles.
  • APC function involves at least four critical groups of events.
  • These events include peptide-MHC complex formation, soluble cytokines, distinct molecular interactions, and in situ APC functions.

Conclusions:

  • A revised, four-component model provides a more accurate representation of APC-T cell interactions.
  • Understanding these diverse events is crucial for advancing T-cell immunology.
  • This broader perspective is essential for developing targeted immunotherapies.