Related Experiment Video
Updated: Jun 14, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Impact of infant feeding practices on childhood obesity
1Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas 77030, USA. nbutte@bcm.edu
Insights
Childhood obesity risk factors in Hispanic children include age, birth weight, parental obesity, and sedentary behavior. Breast-feeding may offer a minor protective effect, but other factors are more significant.
Area of Science:
- Pediatric Endocrinology
- Genetics and Genomics
- Public Health Nutrition
Background:
- Childhood obesity is a complex multifactorial disease.
- Genetic predisposition and environmental factors interact, contributing to the rise in childhood obesity.
- Previous studies on breast-feeding's protective effect against childhood obesity have yielded mixed results due to confounding factors.
Purpose of the Study:
- To identify genetic and environmental risk factors for obesity and its comorbidities in Hispanic children.
- To analyze the association between infant-feeding practices and childhood obesity.
- To determine salient risk factors in a large cohort of Hispanic children.
Main Methods:
- The Viva La Familia Study enrolled 1030 Hispanic children from 319 families.
- Binary logistic regression was used for panel data analysis to compute odds ratios for risk factors.
- Potential risk factors including infant feeding, birth weight, parental obesity, and sedentary activity were assessed.
Main Results:
- Early infant-feeding practices were not found to be significant risk factors for childhood obesity.
- Key independent risk factors identified were: age, birth weight, maternal and paternal obesity, family size, and sedentary activity levels.
- Breast-feeding showed a potentially small protective effect, though residual confounding is possible.
Conclusions:
- While human milk offers benefits for infant development, other factors significantly outweigh infant-feeding practices as determinants of childhood obesity.
- Parental obesity, birth weight, socioeconomic status, and sedentary behaviors are critical targets for intervention.
- Further research is needed to fully elucidate the complex interplay of factors contributing to childhood obesity.
Abstract:
Childhood obesity is a complex disease influenced by genetic and environmental factors and their interactions. The current surge in childhood obesity in the United States is attributable to an interaction between a genetic predisposition toward obesity and a permissive environment. Several recent systematic reviews and meta-analyses have been published on the association between breast-feeding and childhood obesity. In these analyses, adjustment for confounding factors attenuated or nullified the protective effect of breast-feeding on later obesity. The Viva La Familia Study was designed to identify genetic and environmental factors affecting obesity and its comorbidities in 1030 Hispanic children from 319 families. Odds ratios for potential risk factors associated with childhood overweight were computed using binary logistic regression for panel data. Early infant-feeding practices were not significant. Salient independent risk factors for childhood obesity in this cohort of Hispanic children were age, birth weight, maternal obesity, paternal obesity, number of children in the family, and the percentage of awake time spent in sedentary activity. Breast-feeding may have a small protective effect against childhood obesity, although residual confounding may exist. Human milk is exquisitely fitted for optimal infant growth and development and may uniquely modulate neuroendocrine and immunologic pathways involved in the regulation of body weight. Nevertheless, other genetic and environmental determinants such as socioeconomic status, parental obesity, smoking, birth weight, and rapid infancy weight gain far supersede infant-feeding practices as risk factors for childhood obesity.
Related Concept Videos
Regulation of Food Intake
Obesity
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Development of Human Microbiota
Development of the Oral Microbiota

