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Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese
Xiaomin Zhang1, Mei'an He, Longxian Cheng
1Institute of Occupational Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, Hubei 430030, China.
Circulation
|December 25, 2008
Summary
Elevated heat shock protein 60 (Hsp60) levels are linked to increased coronary heart disease (CHD) risk. Acute myocardial infarction also triggers Hsp60 release, highlighting its role in heart conditions.
Area of Science:
- Cardiovascular Science
- Immunology
- Molecular Biology
Background:
- Heat shock protein 60 (Hsp60) is implicated in atherosclerosis pathogenesis.
- The specific role of circulating Hsp60 in coronary heart disease (CHD) requires further investigation.
Purpose of the Study:
- To investigate the association between circulating Hsp60 levels and CHD risk.
- To examine the impact of acute myocardial infarction (AMI) on Hsp60 levels.
Main Methods:
- A case-control study involving 1003 CHD patients and 1003 controls.
- A prospective study monitoring Hsp60 levels in 20 AMI patients post-admission.
- Plasma Hsp60 and anti-Hsp60 antibody levels were quantified using immunoassay.
Main Results:
- Higher plasma Hsp60 levels were significantly associated with increased CHD risk (OR=4.14).
- Elevated Hsp60 and anti-Hsp60 antibody levels synergistically increased CHD risk (OR=2.30).
- Acute myocardial infarction led to a significant increase in Hsp60 levels on days 0 and 1 post-admission.
Conclusions:
- Circulating Hsp60 is an independent risk factor for CHD.
- Combined elevated levels of Hsp60 and anti-Hsp60 antibodies significantly elevate CHD risk.
- Acute myocardial infarction is associated with increased Hsp60 release.
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