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[Indoleamine 2,3-dioxygenase expression in breast cancer patients during chemotherapy]

Kenichi Sakurai1, Katsuhisa Enomoto, Akira Kitajima

  • 1Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|December 25, 2008
PubMed

We evaluated the significance of indoleamine 2,3-dioxygenase (IDO) in recurrent breast cancer patients during chemotherapy. IDO activity can be measured by tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by High Performance Liquid Chromatography (HPLC). The correlations among Trp/Kyn ratio and immunosuppressive acidic protein (IAP) value in pre-chemotherapies or post-chemotherapies were studied. There were no correlations between pre-chemotherapy and post-chemotherapy in IAP values and Trp/Kyn ratio with weekly paclitaxel therapy. And there were no correlations between pre-chemotherapy and post-chemotherapy in IAP values, but Trp/Kyn ratio in post-chemotherapy was higher than re-chemotherapy with tri-weekly docetaxel therapy. These results suggest that the weekly paclitaxel therapy may be less invasive for recurrent breast cancer patients than the tri-weekly docetaxel therapy.

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