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Quinine-induced tinnitus in rats
P J Jastreboff1, J F Brennan, C T Sasaki
1Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Archives of Otolaryngology--Head & Neck Surgery
|October 1, 1991
Summary
Quinine administration in rats induced effects similar to salicylate-induced tinnitus. This suggests quinine may be a useful tool for studying tinnitus perception in animal models, especially since nimodipine treatment reversed the effects.
Area of Science:
- Neuroscience
- Pharmacology
- Auditory Research
Background:
- Tinnitus is a phantom auditory perception affecting millions.
- Salicylates are known to induce tinnitus in humans and animal models.
- A reliable animal model is crucial for understanding tinnitus mechanisms.
Purpose of the Study:
- To investigate quinine as an inducer of tinnitus in an animal model.
- To compare quinine's effects with salicylate-induced tinnitus.
- To explore potential therapeutic interventions for quinine-induced tinnitus.
Main Methods:
- Conditioned suppression experiments were conducted on 54 male-pigmented rats.
- Quinine was administered via injection to induce tinnitus-like effects.
- The calcium channel blocker, nimodipine, was used to test for therapeutic effects.
Main Results:
- Quinine administration altered licking suppression and recovery patterns in rats.
- These changes mimicked those observed with salicylate administration.
- Quinine's effects were dose- and time-dependent.
- Nimodipine dose-dependently abolished the quinine-induced effects.
Conclusions:
- Quinine can serve as a valid agent for inducing tinnitus in rat models.
- The findings support the use of quinine in exploring tinnitus perception.
- Nimodipine shows potential as a therapeutic agent against quinine-induced tinnitus.