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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with
Shamim Ahmad1, Parminder Singh Otaal, Taranjit Singh Rai
1Department of Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Molecular and Cellular Biochemistry
|December 25, 2008
Summary
Pro-inflammatory cytokines like TNF-alpha and IL-6, and NT-proBNP are elevated in dilated cardiomyopathy (DCM) patients. Lower levels correlate with left ventricular (LV) function recovery, suggesting their use as prognostic biomarkers.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- Elevated levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), their soluble receptors, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are noted in dilated cardiomyopathy (DCM).
- The role of these inflammatory markers in relation to left ventricular (LV) function recovery in DCM remains to be fully elucidated.
Purpose of the Study:
- To investigate the association between pro-inflammatory cytokines, their soluble receptors, and NT-proBNP levels with LV function recovery in DCM patients.
- To determine if these markers can serve as prognostic indicators for DCM patients.
Main Methods:
- Forty DCM patients were categorized into two groups: those with no LVEF recovery (n=30) and those with LVEF recovery (n=10).
- Ten healthy individuals served as controls.
- Levels of TNF-alpha, IL-6, TNFR1, TNFRII, gp130, and NT-proBNP were measured and compared between groups.
Main Results:
- Significantly increased levels of TNF-alpha, IL-6, TNFR1, TNFRII, gp130, and NT-proBNP were observed in DCM patients without LVEF recovery compared to those with recovery.
- These inflammatory markers and NT-proBNP were significantly lower in DCM patients who achieved LVEF recovery.
Conclusions:
- Circulating levels of TNF-alpha, IL-6, and NT-proBNP are correlated with left ventricular function recovery in DCM patients.
- These biomarkers show potential for predicting prognosis in DCM.
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