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Inhibin A levels and severity of preeclampsia
Vorapong Phupong1, Krissada Paiwattananupant, Sittisak Honsawek
1Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand. vorapong.p@chula.ac.th
Objective:
To evaluate the use of third trimester inhibin A levels to assess the severity of preeclampsia.
Materials And Methods:
Blood samples were taken from women diagnosed with mild and severe preeclampsia during the third trimester of pregnancy. Blood samples were collected in plain tubes, centrifuged and stored at -80 degrees C until analyzed. All serum samples were measured for inhibin A levels by enzyme-linked immunosorbent assays.
Results:
Inhibin A levels were greater in the severe (1,435.9 +/- 603.2 pg/mL) than in the mild preeclampsia group (1,021.9 +/- 438.8 pg/mL, P = 0.014).
Conclusion:
Inhibin A levels rise with increasing severity of disease. However, there is considerable overlap of serum inhibin A levels in women with mild and severe preeclampsia. Inhibin A is therefore not a useful adjunct for the classification of preeclampsia.
